Jian Han

Research Interests

My research activities focus on nutrition modulation of complex diseases, with an emphasis on iron metabolism. Iron is an essential nutrient for all living cells. It is involved in DNA synthesis, energy production, and enzymatic reactions. It also interacts with other nutrients and modifies the expression of many genes. Both my graduate and post-graduate work emphasized iron storage and transfer protein expression in either normal or diseased conditions. Two major projects are 1) the investigation of iron-induced oxidative stress and neurotoxicity in obesity; 2) the effect of dietary iron manipulation on insulin sensitivity in obese mice.

Recent Publications

• Antoinette Maldonado-Devincci, A Odelade, A Irby-Shabazz, V Jadhav, P Nepal, E Chang, A Chang, Jian Han (2024). (Longitudinal sex-specific impacts of high-fat diet on dopaminergic dysregulation and behavior from periadolescence to late adulthood.). pp. 1-14. Nutritional neuroscience.
• Bo Wang, Vidya Jadhav, Anu Odelade, Evelyn Chang, Alex Chang, Scott Harrison, Antoinette Maldonado-Devincci, Joseph Graves, Jian Han (2023). (High fat diet reveals sex-specific fecal and liver metabolic alterations in C57BL/6J obese mice). (97) 12, pp. 15. 19.
• Vidya Jadhav, Jian Han, Yewande Fasina, Scott Harrison (2022). (Connecting gut microbiomes and short chain fatty acids with the serotonergic system and behavior in Gallus gallus and other avian species). 13, Frontiers in Physiology.
• Jian Han, Pragya Nepal, Anuoluwapo Odelade, Destiny Belton, Frederick Feely, Joseph Graves, Antoniette Maldonado-Devincci (2021). (High-Fat Diet-Induced Weight Gain, Behavioral Deficits, and Dopamine Changes in Young C57BL/6J Mice). 7, pp. 353. Frontiers in Neuroscience.
• Misty Thomas, Akamu Ewunkem, S Boyd, D Williams, A Moore, Kristen Rhinehardt, E Van Beveren, B Yang, A Tapia, Jian Han, Scott Harrison, J Graves, Jr (2021). (Too much of a good thing: Adaption to iron (II) intoxication in Escherichia coli.). (1) 9, pp. 53-67. Evolution, medicine, and public health.
• J Graves, Jr, Akamu Ewunkem, John Ward, C Staley, Misty Thomas, Kristen Rhinehardt, Jian Han, Scott Harrison (2019). (Experimental evolution of gallium resistance in Escherichia coli.). (1) 2019, pp. 169-180. Evolution, medicine, and public health.
• M Kalan, Kalan, Z Taleb , K Fennie, F Jafarabadi, M Dastoorpour, N Hajhashemi, S Rimaz (2019). (Quality of Life and Stigma among People Living with HIV/AIDS in Iran.). (2019) 11, pp. 287—298 . HIV/AIDS - Research and Palliative Care.
• Mohammad Kalan, Hassan Sis, Gregory Goins, Scott Harrison, Vinaya Kelkar, Mohammad Jafarabadi, Jian Han (2018). (The Identification of Risk Factors Associated with Patient and Healthcare System Delays in the Treatment of Tuberculosis in Tabriz, Iran). (1) 18, pp. 174. BMC Public Health.
• Lumei Liu, Aria Byrd, Justin Plummer, Keith Erikson, Scott Harrison, Jian Han (2016). (The Effects of Dietary Fat and Iron Interaction on Brain Regional Iron Contents and Stereotypical Behaviors in Male C57BL/6J Mice). 3, pp. 20. Frontiers in Nutrition.
• Zhijian Xie, Scott Harrison, Suzy Torti, Frank Torti, Jian Han (2013). (Application of circuit simulation method for differential modeling of TIM-2 iron uptake and metabolism in mouse kidney cells. ). (136) 4, pp. 1-9. Frontiers in Physiology.
• Jian Han, W Seaman, D Xiu, W Wang, F Torti, S Torti (2011). (Iron uptake mediated by binding of H-ferritin to the TIM-2 receptor in mouse cells). (8) 6, Plosone.
• G Bailey, Jian Han, Donela Wright, Joseph Graves (2011). (Religously expressed fatalism and the perceived need for science and scientific process to empower agency). (3) 2, pp. 55-58. The international journal of science in society.
• Jian Han, AJ Thompson-Lowrey, A Reiss, V Mayorov, H Jia, V Bousse, NJ Newman, MD Brown (2006). (OPA1 mutations and mitochondrial DNA haplotypes in autosomal dominant optic atrophy). (4) 8, pp. 217-25. Genetic Medicine.
• Jian Han, JR Day, JR Connor, JL Beard (2002). (H and L ferritin subunit mRNA expression in control vs iron-deficient rat brain). (132) pp. 2769-74. Journal of Nutrition.
• Jian Han, J Han, MA Dunn (2000). (Effect of dietary aluminum on tissue non-heme ion and ferritin levels in the chick). (142) pp. 97-109. Toxicology.
• Jian Han, JR Day, JR Connor, JL Beard (2000). (Iron deficiency alters H- and L- ferritin expression in rat brain). (46) pp. 517-528. Cellular and Molecular Biology.