Antoinette M Maldonado-Devincci

Bio

I currently serve as Interim Associate Chair for the Department of Psychology. I am an Associate Professor at North Carolina A&T. My work focuses around binge alcohol exposure during adolescence and its impact on neurobehavioral functioning later in life. I have a particular focus on the neurobiological underpinnings of sex and steroid hormones and their modulation of brain development during adolescence mediating long-term changes in suceptibility to drug and alcohol use disorders.

Research Interests

My current research broadly centers around understanding how sex differences that emerge during adolescence impact long-term changes in brain and behavior using preclinical animal models. I am particularly interested in investigating how drug and alcohol exposure during adolescence changes propensity for 1) alcohol use disorders, 2) mood disorders, and 3) abnormal brain development in adulthood. My research hones in on the developmental neuroendocrinological mechansims. Another area of research includes examining how modifiable environmental factors (i.e., diet exposure) during periadolescence alters long-term changes in affective behaviors and dysregulation in dopaminergic signaling in a sex-specific manner.
My current research projects use a mouse model to determine how sex differences, binge alcohol exposure, and high fat diet exposure during adolescence impact long-term changes in 1) brain sex steroids; 2) affective behaviors; and 3) alcohol drinking in adulthood.

External URL

https://www.neuromdlab.com

Recent Publications

• Antoinette Maldonado-Devincci, A Odelade, A Irby-Shabazz, V Jadhav, P Nepal, E Chang, A Chang, Jian Han (2024). (Longitudinal sex-specific impacts of high-fat diet on dopaminergic dysregulation and behavior from periadolescence to late adulthood.). pp. 1-14. Nutritional neuroscience.
• K Healey, R Waters, S Knight, G Wandling, N Hall, B Jones, M Shobande, J Melton, S Pandey, H Scott Swartzwelder, Antoinette Maldonado-Devincci (2023). (Adolescent intermittent ethanol exposure alters adult exploratory and affective behaviors, and cerebellar Grin2b expression in C57BL/6J mice.). 253, pp. 111026. Drug and alcohol dependence.
• Bo Wang, Vidya Jadhav, Anu Odelade, Evelyn Chang, Alex Chang, Scott Harrison, Antoinette Maldonado-Devincci, Joseph Graves, Jian Han (2023). (High fat diet reveals sex-specific fecal and liver metabolic alterations in C57BL/6J obese mice). (97) 12, pp. 15. 19.
• K Healey, Sandra Kibble, George Kramer, Antoniette Maldonado-Devincci, H. Scott Swartzwelder (2022). (Sex differences in the effects of adolescent intermittent ethanol exposure on exploratory and anxiety-like behavior in adult rats.). 98, pp. 43-50. Alcohol.
• Antoinette Maldonado-Devincci, Joseph Makdisi, Andrea Hill, Renee Waters, Nzia Hall, Mariah Shobande, Anajli Kumari (2021). (Adolescent intermittent ethanol exposure induces sex-dependent divergent changes in ethanol drinking and motor activity during adolescence and adulthood in C57BL/6J mice). In S. Alex Marshall and C. Ghiani, 00, pp. 1-13. Journal of Neuroscience Researcch.
• Jian Han, Pragya Nepal, Anuoluwapo Odelade, Destiny Belton, Frederick Feely, Joseph Graves, Antoniette Maldonado-Devincci (2021). (High-Fat Diet-Induced Weight Gain, Behavioral Deficits, and Dopamine Changes in Young C57BL/6J Mice). 7, pp. 353. Frontiers in Neuroscience.
• Antoinette Maldonado-Devincci, C Kirstein (2020). (Chronic Ethanol Exposure during Adolescence Increases Voluntary Ethanol Consumption in Adulthood in Female Sprague Dawley Rats.). (12) 10, Brain sciences.
• Bo Wang, Antoinette Maldonado-Devincci, L Jiang (2020). (Evaluating line-broadening factors on a reference spectrum as a bucketing method for NMR based metabolomics.). 606, pp. 113872. Analytical biochemistry.
• Rebekah Stevenson, Jessica Hoffman, Antoniette Maldonado-Devincci, Sara Faccidomo, Clyde Hodge (2019). (MGluR5 activity is required for the induction of ethanol behavioral sensitization and associated changes in ERK MAP kinase phosphorylation in the nucleus accumbens shell and lateral habenbula. ). (23) 367, pp. 19-27. Behavioral Brain Research.
• Danielle Gamble, Chloe Josefson, Mary Hennessey, Renee Waters, Brooke Jones, Destiny Belton, Nzia Hall, Taylor Costen, Cheryl Kirstein, Antoinette Maldonado-Devincci (2019). (Social interaction with an alcohol-intoxicated or cocaine-injected peer selectively alters social and drinking behaviors in adolescent male and female rats). (12) 43, pp. 2525-2535. Alcoholism: Clinical and Experimental Research.
• D Gamble, C Josefson, M Hennessey, Arthur Davis, R Waters, B Jones, D Belton, N Hall, T Costen, C Kirstein, Antoinette Maldonado-Devincci (2019). (Social Interaction With an Alcohol-Intoxicated or Cocaine-Injected Peer Selectively Alters Social Behaviors and Drinking in Adolescent Male and Female Rats.). (12) 43, pp. 2525-2535. Alcoholism, clinical and experimental research.
• A Hasirci, Antoinette Maldonado-Devincci, M Beattie, T O'Buckley, A Morrow (2017). (Cellular GABAergic Neuroactive Steroid (3α,5α)-3-Hydroxy-Pregnan-20-One (3α,5α-THP) Immunostaining Levels Are Increased in the Ventral Tegmental Area of Human Alcohol Use Disorder Patients: A Postmortem Study.). (2) 41, pp. 299-311. Alcoholism, clinical and experimental research.
• Richard Bell, Sheketha Hauser, Tiebing Liang, Youssef Sari, Antoinette Maldonado-Devincci, Zachary Rodd (2017). (Rat Animal Models for Screening Medications to Treat Alcohol Abuse and Dependence). 122, pp. 201-243. Neuropharmacology.
• M Beattie, Antoinette Maldonado-Devincci, P Porcu, T O'Buckley, J Daunais, K Grant, A Morrow (2017). (Voluntary ethanol consumption reduces GABAergic neuroactive steroid (3α,5α)3-hydroxypregnan-20-one (3α,5α-THP) in the amygdala of the cynomolgus monkey). (2) 22, pp. 318-330. Addiction Biology.
• Antoniette Maldonado-Devincci, Alexander Kampov-Polevoi, Raechel McKinley, Danielle Morrow, Todd O’Buckley, A. Morrow (2016). (Chronic intermittent ethanol exposure alters stress effects on (3α,5α)-3-hydroxy-pregnan-20-one (3α,5α-THP) immunolabeling of amygdala neurons in C57BL/6J mice). 10, pp. 12. Frontiers in Cellular Neuroscience.
• Matthew Beattie, Antoniette Maldonado-Devincci, Jason Cook, A. Morrow (2016). (The Effects of Acute and Chronic Ethanol Exposure on GABAergic Neuroactive Steroid Immunohistochemistry: Relationship to Ethanol Drinking). In Victor R. Preedy, (Neuropathology of Drug Addictions and Substance Misuse Volume 1: Foundations of Understanding, Tobacco, Alcohol, Cannabinoids and Opioids) pp. 12. Academic Press.
• K Pleil, E Lowery-Gionta, N Crowley, C Li , C Marcinkiewcz, J Rose, N McCall, A Maldonado-Devincci, A Morrow, S Jones, T Kash (2015). (Effects of chronic ethanol exposure on neuronal function in the prefrontal cortex and extended amygdala). 99, pp. 735-49. Neuropharmacology.
• J Cook, S Nelli, M Neighbors, D Morrow, T O'Buckley, Antoniette Maldonado-Devincci, A Morrow (2014). (Ethanol alters local cellular levels of (3α,5α)-3-hydroxypregnan-20-one (3α,5α-THP) independent of the adrenals in subcortical brain regions). (8) 39, pp. 1978-87. Neuropsychopharmacology .
• J Cook, D Werner, Antoniette Maldonado-Devincci, M Leonard, K Fisher, T O'Buckley, P Porcu, T McCown, J Besheer, C Hodge, A Morrow (2014). (Overexpression of the steroidogenic enzyme cytochrome P450 side chain cleavage in the ventral tegmental area increases 3α,5α-THP and reduces long-term operant ethanol self-administration). (17) 34, pp. 5824-34. The Journal of Neuroscience : the official journal of the Society for Neuroscience.
• Antoniette Maldonado-Devincci, M Beattie, D Morrow, R McKinley, J Cook, T O'Buckley, A Morrow (2014). (Reduction of circulating and selective limbic brain levels of (3α,5α)-3-hydroxy-pregnan-20-one (3α,5α-THP) following forced swim stress in C57BL/6J mice). (17) 231, pp. 3281-92. Psychopharmacology.
• Antoniette Maldonado-Devincci, S Stevens, Jr, C Kirstein (2012). (Investigation of age-specific behavioral and proteomic changes in an animal model of chronic ethanol exposure). 829, pp. 471-85. Methods in Molecular Biology (Clifton, N.J.).
• Antoniette Maldonado-Devincci, K Badanich, C Kirstein (2010). (Alcohol during adolescence selectively alters immediate and long-term behavior and neurochemistry). (1) 44, pp. 57-66. Alcohol (Fayetteville, N.Y.).
• Antoniette Maldonado-Devincci, K Alipour, L Michael, C Kirstein (2010). (Repeated binge ethanol administration during adolescence enhances voluntary sweetened ethanol intake in young adulthood in male and female rats). (4) 96, pp. 476-87. Pharmacology, Biochemistry, and Behavior.
• K Badanich, Antoniette Maldonado, C Kirstein (2008). (Early adolescents show enhanced acute cocaine-induced locomotor activity in comparison to late adolescent and adult rats). (2) 50, pp. 127-33. Developmental Psychobiology.
• A Maldonado, L Finkbeiner, C Kirstein (2008). (Social interaction and partner familiarity differentially alter voluntary ethanol intake in adolescent male and female rats). (8) 42, pp. 641-8. Alcohol (Fayetteville, N.Y.).
• A Maldonado, L Finkbeiner, K Alipour, C Kirstein (2008). (Voluntary ethanol consumption differs in adolescent and adult male rats using a modified sucrose-fading paradigm). (9) 32, pp. 1574-82. Alcoholism, Clinical and Experimental Research.
• Kimberly Badanich, Antoniette Maldonado, Cheryl Kirstein (2007). ( Chronic ethanol exposure during adolescence increases basal dopamine in the nucleus accumbens septi during adulthood). (5) 31, pp. 895-900 . Alcoholism, Clinical and Experimental Research.
• Antoniette Maldonado, Cheryl Kirstein (2005). (Cocaine-induced locomotor activity is increased by prior handling in adolescent but not adult female rats). (4) 86, pp. 568-72. Physiology & Behavior.
• Antoniette Maldonado, Cheryl Kirstein (2005). (Handling alters cocaine-induced activity in adolescent but not adult male rats). (2) 84, pp. 321-326. Physiology and Behavior.