Elimelda Ongeri

Research Interests

Research in the Ongeri lab focuses on understanding the cellular and molecular mechanisms underlying the progression of acute and chronic kidney disease. We work with in vitro cell culture systems, mouse models, and samples from human patients. Of specific interest is determining the role of meprin metalloproteases in the progression of ischemia/reperfusion-induced kidney injury and diabetic kidney disease (DKD). For DKD are we also are interested in understanding the basis for health disparities. To this end we seek to identify biomarkers associated with susceptibility genes. These biomarkers are suited for development of diagnostic tools and tools for evaluating therapeutic outcomes for DKD in susceptible populations such as African Americans and Native Americans.

Recent Publications

• Lei Cao, Rashin Sedighi, Ava Boston, Lakmini Premadasa, Jamilla Pinder, George Crawford, Olugbemiga Jegede, Scott Harrison, Robert Newman, Elimelda Ongeri, (2018). (Undiagnosed kidney injury in uninsured and underinsured diabetic African American men and putative role of meprin metalloproteases in diabetic nephropathy). International Journal of Nephrology.
• J Bylander, F Ahmed, S Conley, J-M Mwiza, E Ongeri (2017). (Meprin Metalloproteases Deficiency Associated with Higher Mortality rates and More Severe Diabetic Kidney Injury in Mice with STZ-induced type 1 diabetes.). (https://doi.org/10.1155/2017/9035038) 2017 (2017), pp. 11. Journal of Diabetes Research.
• Barry Martin, Sabena Conley, Regine Harris, Corshe Stanley, Jean-Marie Niyitegeka, Elimelda Ongeri (2016). (Hypoxia Associated Proteolytic Processing of OS-9 by the Metalloproteinase Meprin beta). pp. 11 (https://www.hindawi.com/journals/ijn/2016/2851803/abs/). International Journal of Nephrology.
• Nitin Kumar, P Nakagawa, B Janic, C Romero, M Worou, S Monu, E Peterson , J Shaw , F Valeriote, Elimelda Ongeri, Jean-Marie Niyitegeka , N Rhaleb , O Carretero (2016). (The Anti-Inflammatory Peptide Ac-SDKP is Released from Thymosin β4 by Renal Meprin alpha and Prolyl Oligopeptidase). (1) 308, pp. F56-68. American Journal of Physiology - Renal.
• J-M Niyitegeka, A Bastidas, R Newman, S Taylor, E Ongeri (2015). (Isoform-specific interactions between meprin metalloproteases and the catalytic subunit of protein kinase A: Significance in acute and chronic kidney injury). 308, pp. F56 - F68. American Journal of Physiology - Renal.
• Jean-Marie Niyitegeka, Adam Bastidas , Robert Newman, Susan S.Taylor , Elimelda Ongeri, (2015). (Isoform-specific interactions between meprin metalloproteases and the catalytic subunit of Protein Kinase A: Significance in acute and chronic kidney injury). 308, pp. F56-F68. American Journal of Physiology - Renal.
• Elimelda Ongeri, Odinaka Anyanwu , Brian Reeves, Judith Bond (2011). (Villin and actin in the mouse kidney brush border bind to and are degraded by meprins: significance of this interaction in ischemia reperfusion renal injury). 301, pp. F871-F882. American Journal of Physiology – Renal.
• Elimelda Ongeri, O Anyanwu, W Reeves, J Bond (2011). (Villin and actin in the mouse kidney brush-border membrane bind to and are degraded by meprins, an interaction that contributes to injury in ischemia-reperfusion.). (4) 301, pp. F871-82. American journal of physiology. Renal physiology.
• Elimelda Ongeri, M Verderame, J Hammond (2007). (The TATA binding protein associated factor 4b (TAF4b) mediates FSH stimulation of the IGFBP-3 promoter in cultured porcine ovarian granulosa cells.). (1-2) 278, pp. 29-35. Molecular and cellular endocrinology.
• Elimelda Ongeri, M Verderame, J Hammond (2005). (Follicle-stimulating hormone induction of ovarian insulin-like growth factor-binding protein-3 transcription requires a TATA box-binding protein and the protein kinase A and phosphatidylinositol-3 kinase pathways.). (7) 19, pp. 1837-48. Molecular endocrinology (Baltimore, Md.).
• Elimelda Ongeri, Q Zhu, M Verderame, J Hammond (2004). (Insulin-like growth factor-binding protein-3 in porcine ovarian granulosa cells: gene cloning, promoter mapping, and follicle-stimulating hormone regulation.). (4) 145, pp. 1776-85. Endocrinology.
• C Bormann, Elimelda Ongeri, R Krisher (2003). (The effect of vitamins during maturation of caprine oocytes on subsequent developmental potential in vitro.). (5-6) 59, pp. 1373-80. Theriogenology.
• Elimelda Ongeri, C Bormann, R Butler, D Melican, W Gavin, Y Echelard, R Krisher, E Behboodi (2001). (Development of goat embryos after in vitro fertilization and parthenogenetic activation by different methods.). (9) 55, pp. 1933-45. Theriogenology.
• Elimelda Ongeri, R Krisher (2001). (Glucose and pyruvate metabolism of preimplantation goat blastocysts following in vitro fertilization and parthenogenetic activation.). (3) 3, pp. 115-123. Cloning and stem cells.
• E Wango, D Onyango, D Odongo, E Okindo, J Muweru (1997). (In vitro production of testosterone and plasma levels of luteinizing hormone, testosterone and cortisol in male rats treated with heptachlor). 118, pp. 381-386. Comp. Biochem. Physiol .
• Lei Cao, Ava Boston, Olugbemiga Jegede, Scott Harrison, Robert Newman, Elimelda Ongeri (Inflammation and kidney injury in diabetic African American men). (https://www.ncbi.nlm.nih.gov/pubmed/30868076) 2019, pp. 2019 Feb 5;2019:5359635. doi: 10.1155/2019/5359635. eCollection 2019.. Journal of diabetes research.